Pathogenic Genetic Variants, Comorbid Autism and Adaptive Developmental Quotient as Independent Predictors of Intellectual Disability in Children With Global Developmental Delay: An Interpretable Machine Learning Model With Calibrated Risk Estimation
Background Global developmental delay (GDD) frequently precedes intellectual disability (ID), but no validated multivariable prognostic tool exists to support individualised counselling during the initial diagnostic work-up. Existing risk indicators are typically considered in isolation, and their joint contribution within an interpretable predictive framework remains uncertain. Methods We retrospectively analysed 2453 children diagnosed with GDD between January 2014 and December 2023 at a provincial tertiary ch…

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