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All Diagnostics & Imaging Drug Discovery Mental Health Hospitals & Care

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Predicting Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review of Deep Learning Models for Early-Stage Disease Classification

Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which early diagnosis-particularly the accurate prediction of conversion from mild cognitive impairment (MCI) to AD-is essential to enable timely and effective therapeutic interventions. Deep learning (DL) models have demonstrated substantial promise in this domain; however, critical challenges persist, including multiclass staging of disease progression, longitudinal data modeling, and effective multimodal data integration. Th…

Ageing Research Reviews · Health

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GENERATIVE AI FOR HIRSCHSPRUNG DISEASE: CAN SYNTHETIC FLUORESCENCE CONFOCAL MICROSCOPY IMAGES ENHANCE INTRAOPERATIVE DETECTION OF GANGLIONIC BOWEL?

Background Accurate identification of ganglionated bowel is essential during laparoscopic pull-through for Hirschsprung Disease (HD), yet intraoperative biopsy interpretation is time-sensitive and operator-dependent. Fluorescence confocal microscopy (FCM) provides rapid imaging of fresh tissue, and deep-learning (DL) has the potential to extract diagnostic patterns from these images automatically. However, DL development is limited by HD rarity and images scarcity. Generative-AI may address this gap by synthesiz…

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The impact of digital technology, social media, and artificial intelligence on cognitive functions: a review

In our modern society, digital devices, social media platforms, and artificial intelligence (AI) tools have become integral components of our daily lives, profoundly intertwined with our daily activities. These technologies have undoubtedly brought convenience, connectivity, and speed, making our lives easier and more efficient. However, their influence on our brain function and cognitive abilities cannot be ignored. This review aims to explore both the positive and negative impacts of these technologies on cruc…

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Machine-learning prediction of urine-culture positivity in a multicentre test-ordered cohort: Model development and internal validation

Objectives This study aim to develop, compare and internally validate machine-learning models for predicting urine-culture positivity in patients who had both urinalysis and culture ordered and to explore descriptive probability strata. Post hoc secondary analyses examined age subgroups, the incremental contribution of text-derived features, simpler comparators and calibration. Patients and methods Urine culture results are typically unavailable for 24-72 h, creating uncertainty during initial assessment, and ma…

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FedMediFormer-XAI: Federated Multimodal Transformers with Diffusion Augmentation and Graph-Based Drug Recommendation for Diabetes

Diabetes management faces a number of obstacles, such as fragmented healthcare data, privacy concerns, poor explainability, and the lack of personalized therapeutic guidance. This research work introduces FedMediFormer-XAI, a unified and proper framework that incorporates federated learning, multimodal transformers, diffusion-based data augmentation, Graph Neural Networks (GNNs) for drug recommendation, and Explainable Artificial Intelligence (XAI) for diabetes intelligence. The system utilizes diverse healthcar…

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Advancing preoperative planning technology in total joint arthroplasty with a real-time machine learning calculator: 1-year mortality risk in a value-based care era

Background Technological innovation in total joint arthroplasty (TJA) has largely focused on intraoperative precision through robotics, navigation, and implant design, while preoperative decision-making remains comparatively underdeveloped. Accurate estimation of patient-specific risk is central to surgical indications, yet existing tools provide limited resolution for consequential outcomes such as 1-year mortality. Methods A machine learning model was developed using the TriNetX Research Network. Patients unde…

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Machine Learning for Mortality Prediction in Infective Endocarditis: A Systematic Review and Meta-Analysis

Infective endocarditis (IE) continues to be an often fatal condition despite improvements in cardiac surgical procedures and antibiotic therapy, and conventional scoring tools show poor generalizability. Machine learning (ML) addresses these limitations by capturing complex, nonlinear clinical relationships, outperforming conventional scores in predictive accuracy, though prior ML work in IE has focused on diagnosis. A PRISMA-compliant systematic review and meta-analysis of PubMed (Supplemental Digital Content,…

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Artificial intelligence for lung disease quantification in systemic sclerosis-associated interstitial lung disease and other connective tissue disease-associated interstitial lung disease

Purpose of review Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of disease-related mortality in systemic sclerosis and the connective tissue disease-associated ILD (CTD-ILD) in which artificial intelligence imaging has advanced most rapidly. Visual high-resolution CT (HRCT) scoring is reader-dependent and limits clinical decision-making. This review summarizes clinically relevant artificial intelligence and radiomics publications from approximately the last 18 months, foc…

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Artificial intelligence for lung disease quantification in systemic sclerosis-associated interstitial lung disease and other connective tissue disease-associated interstitial lung disease

How Well Do AI Chatbots Understand Abnormal Anatomy: A Comparative Study Using Congenital Anomalies and Tumor Cases

Artificial Intelligence (AI) chatbots are becoming an efficient option to understand medical data and also help with clinical reasoning. There has been a recent progression in research of large language models and their ability to be used in the healthcare sector, such as radiological image analysis, and diagnostic support. There is however, little evidence supporting their ability to accurately understand abnormal anatomical conditions, such as congenital anomalies and tumor related changes in anatomy. To asses…

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Stakeholder perspectives on artificial intelligence in schizophrenia care

Background Artificial intelligence (AI) is explored as a tool to expand access to mental health care, offering support and self-disclosure. To date, the perspectives of individuals with schizophrenia on AI have been absent from the medical literature. This exploratory study represents an effort to report schizophrenia patient perspectives on AI chatbots through a focus group. Methods We conducted an exploratory, cross-sectional, qualitative study using semi-structured focus groups at a large academic health cent…

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Artificial Intelligence and Complementary Digital Health Technologies Across the Travel Medicine Continuum: A Narrative Review

Background Artificial intelligence (AI) and complementary digital health technologies are increasingly being applied to improve prevention, diagnosis and surveillance in travel medicine. This narrative review evaluates current applications of these technologies across the pre-travel, peri-travel and post-travel phases of the travel continuum. Methods A narrative literature review was conducted using a clinically oriented three-phase framework encompassing pre-travel preparation, peri-travel monitoring and post-t…

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Effect of Large Language Model-Powered Virtual Standardized Patients on History-Taking Among Undergraduate Medical Students: Propensity-Matched Cohort Study

Background Medical history taking (MHT) is a foundational clinical competency for medical students; however, traditional training models using standardized patients face challenges such as resource constraints. Large language model-powered virtual standardized patients (LLM-VSPs) offer a safe, repeatable platform for self-directed practice with AI-automated feedback. Nevertheless, their effectiveness in authentic teaching environments and underlying learning mechanisms require further investigation. Objective Th…

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Beyond the Algorithm: A Stewardship Framework for the Hand Surgeon Adopting Artificial Intelligence

Artificial intelligence is entering hand surgery through imaging, outcome prediction, and patient communication. Neural networks read scaphoid and distal radius radiographs. Machine learning models predict outcomes after carpal tunnel release. Large language models are being tested for patient communication and chart drafting. Adoption, however, has outpaced validation. Most hand surgery artificial intelligence tools are tested only on data resembling their training set, deployed in workflows that have not been…

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Pediatric Artificial Intelligence in Radiology: Unmet Needs and Next Steps-<i>AJR</i> Expert Panel Review

Artificial intelligence (AI) applications have transformed radiology, yet pediatric medical imaging remains substantially underrepresented in AI development, validation, regulation, and implementation. Unlike adults, children go through continuous physiologic and anatomic changes that require age-specific models trained on representative developmental data. However, pediatric AI is limited by scarce publicly available datasets, fragmented institutional data, rare diseases, heterogeneous reporting practices, and…

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A Quality Assessment Rubric for Artificial Intelligence-Generated Patient-Friendly Radiology Reports

Background: Artificial intelligence (AI) tools are being used to translate radiology reports into plain language, but translation errors may compromise comprehension and safety. Objective: To develop and evaluate a rubric for assessing the quality and safety of AI-generated patient-friendly radiology reports. Methods: In this prospective study (conducted from February 2025 to December 2025), survey-workshop cycles, involving lay participants and a multidisciplinary panel, were used to develop a rubric for gradin…

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