Identification of Methionine Metabolism-Driven Heterogeneous Subtypes in Colorectal Cancer and Their Associated Immune Microenvironment
Aim Tumor heterogeneity, driven by metabolic reprogramming, challenges colorectal cancer (CRC) treatment. Methionine metabolism is crucial for tumor progression, but its role in CRC heterogeneity and the tumor immune microenvironment (TIME) requires systematic investigation. Methods A systematic evaluation of 101 combinations of machine learning and statistical algorithms was conducted within a 10-fold cross-validation framework to develop and validate the optimal model, termed the methionine metabolism-related…
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