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Deep Learning-Based Classification of NIFTP and Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma Using Gross Pathology Images

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) are diagnostically challenging thyroid neoplasms with overlapping clinical and molecular characteristics. Although artificial intelligence has shown promise for diagnostic support in radiology and histopathology, its application to gross pathology remains unexplored. This study analyzed gross pathology photographs from 87 patients (43 with NIF…

Journal of Imaging Informatics in Medicine · Health

Deep Learning-Based Classification of NIFTP and Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma Using Gross Pathology Images

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Reinventing the echocardiography workflow: from manual quantification to artificial intelligence-driven comprehensive interpretation

Echocardiography remains the cornerstone of cardiovascular imaging. However, traditional workflows including manual acquisition, sequential measurement, and expert interpretation face challenges from increased clinical demand, workforce shortage, and the physical burden of repetitive scanning. Artificial intelligence (AI) has begun to address these issues, transitioning from proof-of-concept to prospective clinical evaluations. Recent evidence suggests that AI integration reduces examination time and automates m…

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Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire

The adaptive immune receptor repertoire (AIRR) - the collection of an individual's B-cell and T-cell receptors (BCRs and TCRs, respectively) - encodes cumulative immune history and is shaped by both germline genetics and environmental exposures. Skewed repertoires have been linked to infections, vaccination responses and autoimmune diseases such as celiac disease (CeD) where biased usage of immunoglobulin and T-cell receptor genes reactive to disease relevant antigens has been reported. Motivated by evidence tha…

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Pulmonary Artery-to-Vein Volume Difference: A New Imaging Biomarker for Risk Stratification in Acute Pulmonary Embolism

Rationale and objectives To propose a new imaging biomarker, the pulmonary artery-to-vein volume difference (PAVVD), and evaluate its efficacy in risk stratification of acute pulmonary embolism (APE) compared with traditional computed tomography pulmonary angiography (CTPA) parameters, as well as the impact of chronic pulmonary disease (CPD). Materials and methods This retrospective study included 134 patients with APE (high/intermediate-high risk, n = 46; intermediate-low/low risk, n = 88) from April 2023 to Ma…

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International Application of Artificial Intelligence for Lesion Detection on Digital Breast Tomosynthesis: Comparing Western and Eastern Databases

Rationale and objectives The international application of artificial intelligence (AI) for lesion detection based on digital breast tomosynthesis (DBT) is limited due to disease variations among populations. We hypothesized that lesion detection models trained on either the Western or Eastern DBT dataset would exhibit reduced performance on another dataset. We proposed transfer learning to enhance lesion detection across DBT databases. Materials and methods The Western database (94 patients) was obtained from th…

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Predicting Synchronous Liver Metastasis in Pancreatic Cancer Using CT Radiomics and Clinical Features: A Machine Learning Approach

Rationale and objectives To address the challenge of preoperative prediction of synchronous liver metastasis (LM) in pancreatic cancer (PC), we developed and validated machine learning models integrating clinical and computed tomography (CT) radiomics features, and compared the performance and interpretability of linear (linear discriminant analysis [LDA]) versus nonlinear (multilayer perceptron [MLP]) architectures. Materials and methods This retrospective study enrolled 340 patients with pancreatic ductal aden…

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Attitudes, perceptions, and UTAUT-based factors influencing the acceptance of medical artificial intelligence among Chinese oncology healthcare professionals: a national cross-sectional survey

Objectives To conduct a nationwide survey among professionals working in oncology departments in China to investigate their attitudes, perceptions, and experiences regarding medical artificial intelligence (AI), and to explore and compare the factors influencing AI behavioral intention (BI; willingness to adopt AI) between physicians and nurses using the Unified Theory of Acceptance and Use of Technology (UTAUT). Materials and methods A nationwide cross-sectional survey was conducted among professionals in oncol…

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An Explainable Computer-Aided Framework for Skin Lesion Classification Using Deep Learning

The utilization of deep convolutional neural networks for the purpose of diagnosing diseases in the skin area has proven to yield similar accuracy levels to those obtained by dermatologists in different studies. Nevertheless, many challenges are still present, including underperformance and poor generalization in some cases, as well as low interpretability related to the use of black box models. This creates major obstacles for practical implementation since it requires explainability in addition to accurate dia…

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An Explainable Computer-Aided Framework for Skin Lesion Classification Using Deep Learning

Deep Learning for Synthetic Postcontrast T1-Weighted MRI: A Systematic Review With Targeted Meta-Analysis of Brain Tumor Studies

BACKGROUND . Gadolinium-based contrast agents remain essential for MRI but carry risks. Deep learning (DL) methods have emerged as a potential approach for synthesizing postcontrast T1-weighted images from precontrast sequences alone. OBJECTIVE . The objective of the present study was to systematically review DL-based synthesis of postcontrast T1-weighted MRI, characterize model architectures and evaluation practices across subspecialties, and perform targeted meta-analysis where sufficient literature existed. E…

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Deep Learning for Synthetic Postcontrast T1-Weighted MRI: A Systematic Review With Targeted Meta-Analysis of Brain Tumor Studies

AI-ICE Guided Pulsed Field Ablation of Atrial Fibrillation with Variable Loop Circular Catheter

Background Intracardiac echocardiography (ICE) facilitates left atrial (LA) reconstruction during atrial fibrillation (AF) ablation. The artificial intelligence-based CARTOSOUND FAM (AIFAM) module enables automated three-dimensional LA reconstruction without the need for a dedicated pre-ablation mapping catheter. While this workflow has been described previously in radiofrequency ablation, its application and outcome in pulsed field ablation (PFA) remains limited. Objective To evaluate the feasibility, safety, a…

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Intramuscular Fat Assessed by AI-Assisted Muscle Ultrasound: Association With Cardiometabolic Risk Factors and Diabetic Nephropathy in Diabetes Mellitus

Aims Intramuscular fat (IMF) is increasingly recognized as a marker of ectopic adiposity and adverse cardiometabolic outcomes. Artificial intelligence (AI)-assisted ultrasound of the rectus femoris (RF) offers a non-invasive approach for quantifying IMF. This study evaluated the association of IMF with diabetes-related complications (particularly diabetic nephropathy) and metabolic risk factors in patients with diabetes mellitus (DM). Materials and methods In this cross-sectional study, outpatients from a tertia…

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Intramuscular Fat Assessed by AI-Assisted Muscle Ultrasound: Association With Cardiometabolic Risk Factors and Diabetic Nephropathy in Diabetes Mellitus

Stacked Ensemble Deep Learning Models for Accurate Detection and Size Stratification of Periapical Lesions on Intraoral Radiographs

Periapical lesions are challenging to detect on intraoral radiographs because of anatomical superimposition and reader variability. This study developed stacked deep learning ensembles for automated detection and radiographic size stratification of periapical lesions. In total, 146 radiographs comprising normal cases and three lesion-size categories were cropped around the root apex and augmented using predefined transformations. Five convolutional neural network backbones were trained, and their probability out…

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Stacked Ensemble Deep Learning Models for Accurate Detection and Size Stratification of Periapical Lesions on Intraoral Radiographs

Robotic Ultrasound Imaging: A Comprehensive Review of Historical Evolution, Current State-of-the-Art, and Future Perspectives

Ultrasound imaging is an indispensable diagnostic tool, yet its profound reliance on operator expertise inherently restricts its reproducibility and global accessibility. Robotic ultrasound systems (RUSS) have evolved over the past 2 decades to mitigate these limitations by mechanically decoupling the human operator from the patient. This comprehensive review examines the historical trajectory of medical ultrasonography and robotics, highlighting their convergence into modern RUSS. We detail the taxonomies of ro…

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Adaptation of a fair individualized polysocial risk score for hospitalization risk prediction

Objectives We adapted the individualized polysocial risk score (iPsRS), a machine learning model originally developed for patients with type 2 diabetes, to evaluate its generalizability in predicting 1-year hospitalization risk in a disease-agnostic adult cohort, with attention to fairness and explainability. Materials and methods The study utilized de-identified electronic health record data from a retrospective cohort of 17 857 adult patients at the University of Florida Health. The original iPsRS framework wa…

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Adaptation of a fair individualized polysocial risk score for hospitalization risk prediction

Diagnosing melioidosis and tracking treatment outcomes using breath

Melioidosis is a life-threatening infectious disease caused by Burkholderia pseudomallei ( Bp ). Rapid diagnosis and appropriate antimicrobial treatment are critical to reduce mortality, yet diagnosis is hindered by diverse clinical manifestations, mimicry with other diseases, and reliance on slow culture-based methods. Detecting volatile compounds offers a non-invasive approach for rapid infection detection. In this study, we aim to identify volatile compounds in patients' breath that can aid in diagnosing meli…

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Diagnosing melioidosis and tracking treatment outcomes using breath