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Development and external validation of a multimodal artificial intelligence mortality prediction model of critically ill patients using multicenter data

Background Early prediction of in-hospital mortality in critically ill patients can aid clinicians in optimizing treatment. The objective was to develop a multimodal deep learning model, using structured and unstructured clinical data, to predict in-hospital mortality risk among critically ill patients after their initial 24 hour intensive care unit (ICU) admission. Methods We used data from MIMIC-III, MIMIC-IV, eICU, and HiRID. A multimodal model was developed on the MIMIC datasets, featuring time series compon…

Anesthesiology · Health

Development and external validation of a multimodal artificial intelligence mortality prediction model of critically ill patients using multicenter data

Evidence-backed gain

The FERM guild: a differentially correlated microbial module drives hypertension via metabolic flux perturbations

Hypertension is a major risk factor for cardiovascular diseases, with changes in gut microbiota composition and function being closely associated with its onset and progression. However, the high inter-individual variability in gut microbiota complicates the identification of pathogenic mechanisms using traditional methods. In contrast, the smaller variability in gut microbial metabolites offers a more reliable and consistent basis for cross-individual comparisons. Parsimonious flux balance analysis (pFBA), inte…

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Accuracy of Artificial Intelligence based chatbots in reporting jaw lesions from multimodal radiographic images: A cross-sectional study

Objectives The current study aimed to quantify the diagnostic accuracy of commonly utilized chatbots including Gemini, Copilot, Claude, and specialized architectures like Manus in the detection and differential diagnosis of various jaw lesions, while concurrently evaluating the clinical safety and fidelity of the information they provide. Materials and methods Cone beam computed tomography (CBCT) dataset from 97 patients presented with jaw lesions were collected and anonymized. Panoramic 2D views were reconstruc…

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Long-term prediction of epilepsy following traumatic brain injury among veterans using routine clinical data

Objective Despite elevated risk for epilepsy following traumatic brain injury (TBI), there are limited tools to assess epilepsy risk following TBI using routine clinical data. The objective of this study was to develop and validate a machine learning approach to predict the onset of posttraumatic epilepsy (PTE) over varying time horizons following TBI, using only routine clinical data collected up to the month of TBI documentation. Methods This retrospective longitudinal cohort study included post-9/11 US vetera…

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AI-Assisted Electrocardiogram Interpretation Improves ST-Elevation Myocardial Infarction Diagnostic Accuracy Among Advanced Practice Providers: A Prospective Randomized Crossover Study

Timely and accurate diagnosis of ST-elevation myocardial infarction (STEMI) is critical in military operational environments where evacuation may be delayed. Although artificial intelligence (AI) electrocardiogram (ECG) tools have demonstrated high diagnostic performance, their effectiveness among advanced practice providers (APPs) remains untested. This study evaluated whether AI-ECG interpretation by Queen of Hearts (QoH) AI software by PMcardio improves STEMI diagnostic accuracy, clinician confidence, and tim…

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Prognostic risk modeling based on integrated multi-omics analysis identifies CRY2 as a key regulator in tumor immunity and patient survival in colorectal cancer

Colorectal cancer (CRC) exhibits substantial metabolic heterogeneity. This study developed a robust prognostic signature integrating ferroptosis- and lipid metabolism-related genes to investigate the role of CRY2 in CRC progression. Transcriptomic and clinical data from the TCGA-COAD and GSE39582 cohorts were analyzed. Weighted gene co-expression network analysis (WGCNA) was performed to identify disease-associated gene modules. A machine learning framework was subsequently applied to construct and optimize the…

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Trustworthy artificial intelligence for rural health care

Regional, rural and remote Australians experience poorer health outcomes and substantially higher rates of suicide and self-harm than those in major cities. Artificial intelligence could support earlier identification of distress, safer triage and more timely care alongside telehealth and clinical decision support, but only if it is treated as a health intervention with explicit safety nets and independent evaluation. We propose a minimum viable governance model, including Indigenous partnership, language safety…

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Mapping the Evolving AI Preferences and Care Needs in Orthopedic Transitional Care From Hospitals to Home: Cross-Sectional Study

Enhanced recovery after surgery protocols have shortened orthopedic hospital stays but have shifted rehabilitation and safety-monitoring tasks to patients and families after discharge. In this study, AI refers to patient-facing digital systems for orthopedic transitional care, including large language model chatbots, computer vision or platform-based monitoring tools, and wearable sensor-enabled systems for education, rehabilitation guidance, motion correction, and risk alerts. However, patient-reported preferen…

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Mapping the Evolving AI Preferences and Care Needs in Orthopedic Transitional Care From Hospitals to Home: Cross-Sectional Study

Between the hype and harm: does artificial intelligence in health offer solace or further exclusion for marginalised populations in Sub-Saharan Africa? A scoping review

Artificial intelligence (AI) is increasingly being integrated into healthcare systems and has the potential to improve health outcomes. In Sub-Saharan Africa (SSA), however, concerns remain that AI may either reduce or exacerbate existing health inequities depending on how it is developed, governed, and implemented. This scoping review aimed to map and synthesise the existing evidence on the implications of AI for health equity among marginalised populations in Sub-Saharan Africa. PubMed, Web of Science, Scopus,…

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Sleep Diagnostics and Monitoring Technology in Obstructive Sleep Apnea

Objective This article helps neurologists understand modern approaches to diagnosing obstructive sleep apnea, including the clinical role and limitations of home sleep apnea testing, and learn how they can integrate wearable and noncontact technologies into patient care to improve diagnostic efficiency, monitor treatment, and reduce health disparities. Latest developments Advances in home sleep apnea testing have expanded beyond traditional type III monitors to include wearable devices such as wrist sensors and…

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Comparison of Machine Learning and Logistic Regression in Predicting Mortality from Acute Poisoning in Young Adults: A Multicenter Study Identifying Herbicide Exposure as the Predominant Risk Determinant

Objective Compare the effectiveness of machine learning algorithms and traditional logistic regression in predicting the mortality risk of young patients with acute poisoning, and establish a risk stratification nomogram. Methods This multicenter retrospective study derived a derivation cohort of 406 young adults with acute poisoning from Wenzhou and an external validation cohort of 150 patients from Lishui.LASSO regression was used to screen predictive factors from 43 candidate variables. Compare the predictive…

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Artificial intelligence in the radiologic diagnosis of major urological cancers: a meta-analysis

Objective Given the pivotal role of imaging in diagnosing urological cancers, artificial intelligence (AI) has emerged as a promising tool to improve diagnostic accuracy and reliability. This study systematically evaluates the diagnostic performance of AI models in radiologic imaging of urological cancers. Methods A systematic search was conducted in four electronic databases up to June 2026 to identify studies that applied AI algorithms for the diagnosis of urological cancers using CT, MRI, or ultrasound. Eligi…

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Artificial intelligence in the radiologic diagnosis of major urological cancers: a meta-analysis

Functional outcome prediction after traumatic cervical spinal cord injury using ensemble machine learning: a three‑center validation study

Background Traumatic cervical spinal cord injury (TCSCI) often causes severe neurological dysfunction. Accurate prediction of functional recovery is essential for clinical decision‑making and rehabilitation planning. Objective To develop an ensemble learning model integrating baseline clinical data, neurological assessments, and cervical MRI features to predict neurological recovery and functional outcomes at one year post‑injury in TCSCI patients. Methods We retrospectively collected data from 410 TCSCI patient…

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Functional outcome prediction after traumatic cervical spinal cord injury using ensemble machine learning: a three‑center validation study

Promises and limitations of deep learning for predicting knee osteoarthritis progression from medical imaging: A systematic review

To systematically evaluate the performance, methodological quality, and translational barriers of deep learning (DL) models for predicting knee osteoarthritis (KOA) progression from medical imaging. Following PRISMA guidelines, we searched PubMed, Scopus, and Web of Science (inception to June 2026) for peer-reviewed studies applying DL to predict KOA progression from medical imaging. Two reviewers independently screened studies, extracted data, and assessed risk of bias using PROBAST-AI. The primary outcome was…

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Promises and limitations of deep learning for predicting knee osteoarthritis progression from medical imaging: A systematic review

Establishing diagnostic thresholds for adult ADHD screening in taxi drivers: validation of the CAARS-S via Item Response Theory and Machine Learning

Background Adult Attention-Deficit/Hyperactivity Disorder (ADHD) is under-recognized in professional drivers, yet it poses significant safety risks. The Conners' Adult ADHD Rating Scale Short Version (CAARS-S:SV) lacks empirically validated cutoff scores for occupational screening in Iran. This study aimed to assess the psychometric properties of the Persian CAARS-S:SV in taxi drivers and to determine optimal ADHD diagnostic thresholds using both traditional and machine-learning methods. Methods A sample of 298…

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